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Once in a lifetime tours

Extending beyond the realms of the ordinary holiday, some journeys may be considered truly life-changing. These are unforgettable trips which, by combining iconic or exotic destinations with authentic cultural experiences and extraordinary sights and activities, can only fittingly be described as 'once in a lifetime holidays'.

Great Rail Journeys is proud to offer a range of these momentous and life-affirming holidays. Take, for example, a journey on the legendary Trans-Siberian Express. This 8,000-mile odyssey - the longest rail journey in the world and the number one experience on countless travellers' bucket list - takes in the best of Russia's magnificent cities, natural landscapes and culture as our guests travel aboard one of the world's most luxurious private trains.

Incomparable romance and elegance inform the journey of a lifetime on board the Venice Simplon-Orient-Express. Immortalised in literature and on film, this remarkable train harks back to a golden era of travel. Those who join Great Rail Journeys on an adventure which takes in the spectacular Alps, Paris, Milan and Venice are assured the highest standards of luxury, service and cuisine and an experience that will reward them with a lifetime of cherished memories.

Whatever the nature of your perfect once in a lifetime holiday, Great Rail Journeys can provide the magical destinations, sights, experiences and activities that will satisfy your wildest dreams.

34 results matching: Once in a Lifetime Escorted Tours

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Worldwide Escorted Holidays by Rail 2022

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Classic Glacier Express
Small Group
4.7 stars(34 reviews)
2022MarAprMayJunJul...
9 days from
£2,095 pp
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9 days from
£2,095
per person
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tour map
  • DestinationSwitzerland
  • Starts / EndsSt Pancras International
  • AccommodationHotel
  • TransportRail
Map and accommodation
New England in the Fall
4.5 stars(20 reviews)
2022SepOct
10 days from
£2,595 pp
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10 days from
£2,595
per person
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tour map
  • DestinationUSA
  • Starts / EndsLondon Heathrow
  • AccommodationHotel
  • TransportFlight, Rail, Coach
Map and accommodation
Taj Mahal, Agra
4.7 stars(7 reviews)
2022AprSepOctNovDec
14 days from
£1,995 pp
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14 days from
£1,995
per person
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tour map
  • DestinationIndia
  • Starts / EndsLondon Heathrow
  • AccommodationHotel
  • TransportFlight, Rail, Coach
Map and accommodation
4 days from
£635
per person
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tour map
  • DestinationScotland
  • AccommodationHotel
  • TransportRail, Coach
Map and accommodation
Sirmione on Lake Garda
Small Group
4.5 stars(46 reviews)
2022AprMayJunJulAug...
10 days from
£1,895 pp
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10 days from
£1,895
per person
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tour map
  • DestinationItaly
  • Starts / EndsLondon
  • AccommodationHotel
  • TransportRail, Coach
Map and accommodation
USA Coast to Coast
4.8 stars(24 reviews)
2022AprMayJunAugSepOct
18 days from
£3,995 pp
View Details
18 days from
£3,995
per person
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tour map
  • DestinationUSA
  • Starts / EndsLondon Heathrow
  • AccommodationRail, Hotel
  • TransportFlight, Rail, Coach
Map and accommodation

Worldwide 2022 Brochure

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Vietnam, Cambodia & the Mekong Delta
4.8 stars(31 reviews)
2022AprSepOctNovDec
18 days from
£3,295 pp
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18 days from
£3,295
per person
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tour map
  • DestinationCambodia, Vietnam
  • Starts / EndsLondon Heathrow
  • AccommodationRail, Hotel
  • TransportFlight, Rail, Coach
Map and accommodation
Canada Coast to Coast rail holiday
4.5 stars(11 reviews)
2022MayJunAugSep
16 days from
£3,995 pp
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16 days from
£3,995
per person
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tour map
  • DestinationCanada
  • Starts / EndsLondon Heathrow
  • AccommodationRail, Hotel
  • TransportFlight, Rail, Coach
Map and accommodation
8 days from
£2,645
per person
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tour map
  • DestinationGermany
  • Starts / EndsSt Pancras International
  • AccommodationHotel
  • TransportRail
Map and accommodation
Milford Sound
4.7 stars(9 reviews)
2022SepOctNov
21 days from
£4,995 pp
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21 days from
£4,995
per person
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tour map
  • DestinationNew Zealand
  • Starts / EndsLondon Heathrow
  • AccommodationHotel
  • TransportFlight, Rail, Coach
Map and accommodation
Highlights of Canada in Winter
2022FebMar
11 days from
£2,595 pp
View Details
11 days from
£2,595
per person
View Details
tour map
  • DestinationCanada
  • Starts / EndsLondon Heathrow
  • AccommodationRail, Hotel
  • TransportFlight, Rail, Coach
Map and accommodation
The Passion Play
2022MayJun
11 days from
£3,395 pp
View Details
11 days from
£3,395
per person
View Details
tour map
  • DestinationGermany
  • Starts / EndsSt Pancras International
  • AccommodationCruise
  • TransportRail, Cruise
Map and accommodation
Our customers love our Once in a Lifetime Tours tours
A Grand Tour of Italy
21/Oct
P Harris
5 stars
“Really great time
Collected by Trustpilot
Sirmione on Lake Garda
12/Oct
Peter Else
5 stars
“wonderful location great hotel very friendly staff tour leader was brilliant Another well organised tour by GRJ
Collected by Trustpilot
India’s Golden Triangle, Tigers and Shimla
13 Mar 2020
Mrs K Harper
5 stars
“EXCELLENT HOLIDAY, PROFESSIONAL FRIENDLY SERVICE PROVIDED BY THE KNOWLEDGEABLE GUIDES.
Collected by Great Rail Journeys
Ultimate Australia and the Ghan
08 Mar 2020
Mr N Larvin
5 stars
“A well organised experience. You leave everything to the tour manager. Just turn up when they say. Australia is a lovely country to visit.
Collected by Great Rail Journeys
America Coast to Coast
31 Oct 2019
Mr M Green
5 stars
“Loved everything and everywhere- went with an open mind. Obviously some places were better than others but still enjoyed all
Collected by Great Rail Journeys
New England in the Fall
Oct 22 2019
Miss R Palmer
5 stars
“A good itinerary, a good tour guide and a very good crowd------
Collected by Great Rail Journeys
India's Golden Triangle
28 Apr 2019
Mr D Knights
5 stars
“Well organised well informed. Ivan the tour manager was fantastic. Hemms the local guide was full of knowledge and kept us well informed. All tours throughout were fantastic and made the holiday.
Collected by Great Rail Journeys
Ultimate Rajasthan and the Palace on Wheels
21 Dec 2018
Mrs A Liggett
5 stars
“The tour was absolutely excellent. The accommodation, the restaurants chosen, the itinerary, were all superb as were the guides everywhere.
Collected by Great Rail Journeys
Canada Coast to Coast
23 Oct 2018
Mrs A Moehead
5 stars
“Fantastic experience Kay our tour manager was very professional and helpful. Thoroughly enjoyed the company of our fellow travelers. The accommodation was superior and the overnight stays and tours excellent
Collected by Great Rail Journeys

At Great Rail Journeys we make every effort to ensure that your once in a lifetime holiday offers you the best possible experience. With us you can make the ultimate American trip, travelling coast to coast across the USA by train and enjoying spectacular changing scenery, iconic cities and landmarks plus the culture, food and hospitality for which this nation is famous.

For the last word in historic opulence we invite you to experience the splendours of India aboard the famous Palace on Wheels - a train virtually unsurpassed in its heritage and opulence. Truly worthy of anyone's bucket list, this magnificent journey offers the chance to see the Taj Mahal, visit beautiful colonial forts and cities and perhaps to enjoy a rare encounter with Indian tigers in the wild.

If your dream holiday would combine spectacular mountains, lakes and forests with abundant wildlife and time spent exploring compelling, friendly cities a trip with us to Canada and the chance to ride the famous Rocky Mountaineer ticks every box and many more besides.

In the safe and knowledgeable hands of one of our expert Tour Managers, when you join us for your holiday of a lifetime we guarantee you an itinerary that is packed with wonderful experiences and activities, plus all of the free time you need to explore our incredible destinations for yourself. With everything taken care of by Great Rail Journeys all that's left for you to do is relax and enjoy the most special rail holiday you can imagine.

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