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Italy, Southern Europe & Mediterranean Rail Tours & Vacations

The golden sun warms the landscape and travelers' souls in Southern Europe countries. Blue skies adjoin even bluer waters, and rolling countrysides fade into fascinating cities, where the offerings are as exotic as the surroundings. A Mediterranean trip itinerary may begin in Italy - a country renowned for its rich culture, incredible cuisine, luscious wine, pretty towns, and cosmopolitan cities. Trips may also dedicate their entirety to discovering the intricacies of this world-class destination from top to toe, exploring its ancient sites, like Pompeii, and its stunning coastlines between memorable excursions. Explore regions like Tuscany where a little bit of everything can be found, from local cuisines and wines to historic art to hiking the Tuscan hills. Mediterranean vacation packages may also venture to Spain, connecting coastal Barcelona with Madrid or Seville on the interior by high-speed train. Spanish traditions and undeniable ambiance surround each destination. Travelers can also connect Spain's cities with Portugal's incredible Douro wine region by embarking on a river cruising expedition aboard a luxurious ship. Closer to Portugal's oceanside, Porto - beloved for its Port Wine production - and the colorful city of Lisbon further weave the story of Southern Europe. Whether embarking on a guided tour or an independent adventure, it is hard not to fall in love with the vibrancy of the Mediterranean.

Explore Our Top Vacations in Italy, Southern Europe & Mediterranean

Florence Italy
4.3 stars(75 reviews)
Escorted
2027MayJunSepOct
8 days from
$3,199 pp
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Rome Skyline
4.2 stars(204 reviews)
Escorted
2027AprMayJunAugSepOct
9 days from
$3,499 pp
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Cinque Terre
Escorted
2027MarAprMayJunJul...
11 days from
$3,299 pp
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Sagrada Familia Cathedral, Barcelona
Escorted
2027MaySepOct
11 days from
$5,799 pp
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Frecciarossa
Escorted
2027AprMayJunSepOct
12 days from
$4,299 pp
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PIsa
4.3 stars(80 reviews)
Escorted
2027AprMayJunSepOct
15 days from
$5,699 pp
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32 results matching: Italy, Southern Europe & Mediterranean

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Cinque TerreCinque TerreCinque TerreCinque TerreCinque Terre
Escorted
2027MarAprMayJunJul...
Escorted

Travel through centuries of history on this journey of cultural epicenters and romantic views. Staying in four bases, Venice, Montecatini Terme, Rome and Sorrento, uncover Italian wonders from coast to coast with the convenience of well-connected railways.  Begin in the "Floating City," discovering its canals before moving onto Tuscany to explore...

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11 days from
$3,299 pp
per person
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PIsaPIsaPIsaPIsaPIsa
4.3 stars(80 reviews)
Escorted
2027AprMayJunSepOct
Escorted

From the alpine foothills to Sicily and all that lies between, uncover Italy's rich culture on an expertly crafted itinerary. See the highlights of Italy while traveling the country's length, delving into remarkable destinations, including Venice, Florence and Rome.  Bask in the beauty of the Amalfi Coast and marvel at the remains of ancient...

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15 days from
$5,699 pp
per person
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Piazza Navona, RomePiazza Navona, RomePiazza Navona, RomePiazza Navona, RomePiazza Navona, Rome
4.5 stars(6 reviews)
Escorted
2027AprMayJunAugSepOct
Escorted

From Europe's exciting cityscapes to the stunning heights of the Swiss Alps and the idyllic Tuscan countryside, this 13-day exploration opens the doors to Europe's rich history, culture and traditions. Uncover iconic landmarks in London, sail along the romantic Seine in Paris and marvel at Switzerland's stunning Alps during a lake cruise and...

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13 days from
$6,199 pp
per person
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Eiffel Tower ParisEiffel Tower ParisEiffel Tower ParisEiffel Tower ParisEiffel Tower Paris
Escorted
2027AprMayJunSepOct
Escorted

Traveling by First Class rail, discover landmark-lined rivers, alpine peaks and iconic cities while delving into the heart of Europe, relishing its best features from varied perspectives. Begin under the Eiffel Tower in Paris, cruising the Seine and touring its sites before venturing into the Swiss Alps, staying in the medieval city of Lucerne. ...

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11 days from
$5,199 pp
per person
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Cinque TerreCinque TerreCinque TerreCinque TerreCinque Terre
Escorted
2027AprMayJunSepOct
Escorted

This superb Mediterranean adventure features five dazzling cities - Barcelona, Carcassonne, Nîmes, Nice and Genoa - and the idyllic French and Italian Rivieras. From Barcelona's Gothic Quarter and its unique culture, discover the medieval citadel of Carcassonne, and savor a private lunch with wine tasting at a French Château. Explore...

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12 days from
$4,699 pp
per person
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Florence ItalyFlorence ItalyFlorence ItalyFlorence ItalyFlorence Italy
4.3 stars(75 reviews)
Escorted
2027MayJunSepOct
Escorted

Join us on a tour of six of Italy's great historic cities, travelling by First Class rail throughout. Encounter a wealth of artistic and cultural treasures, with guided tours of ancient Rome and the world's Renaissance capital, Florence. On day trips to the walled Tuscan city of Lucca, Pisa's iconic tower and gleaming Duomo, the beautiful town of...

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8 days from
$3,199 pp
per person
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Rome SkylineRome SkylineRome SkylineRome SkylineRome Skyline
4.2 stars(204 reviews)
Escorted
2027AprMayJunAugSepOct
Escorted

 Uncover the beauty of one of Europe's most enchanting regions, the captivating Amalfi Coast.     The journey begins with two nights in the "Eternal City" of Rome, where ancient landmarks and vibrant culture set the stage. From here, continue to the charming clifftop town of Sorrento, overlooking the Bay of Naples, the gateway to Capri and the...

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9 days from
$3,499 pp
per person
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FrecciarossaFrecciarossaFrecciarossaFrecciarossaFrecciarossa
Escorted
2027AprMayJunSepOct
Escorted

Experience the diverse culture of southern Italy and the sun-drenched island of Sicily on this captivating vacation, immersing yourself in history, landscapes and local cuisine. Each stop reveals layers of local character - from the unique trulli of Alberobello and the cave dwellings of Matera to Sicily's awe-inspiring Greek temples, ornate...

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12 days from
$4,299 pp
per person
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Lake LucerneLake LucerneLake LucerneLake LucerneLake Lucerne
Escorted
2027AprMayJunJulAugSep
Escorted

Experience the breathtaking wonders of two countries on one trip during this spectacular exploration of Switzerland and northern Italy. Discover sparkling Lake Lucerne from a lakefront hotel, including a trip to the summit of Mount Rigi on Europe's first mountain railway. Traveling through alpine scenery on the iconic Gotthard Panorama Express,...

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10 days from
$4,699 pp
per person
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Granada AlhambraGranada AlhambraGranada AlhambraGranada AlhambraGranada Alhambra
4.5 stars(86 reviews)
Escorted
2027MaySepOct
Escorted

Discover the rich cultural heritage and artistry of Spain on a journey through its iconic cities. From Barcelona, travel to coastal Valencia and into the capital, Madrid, before exploring Moorish Andalucía. View the astonishing exterior of Gaudí's unfinished masterpiece in Barcelona, savor authentic cuisine in Valencia and Madrid and ...

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11 days from
$5,199 pp
per person
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Pantheon, RomePantheon, RomePantheon, RomePantheon, RomePantheon, Rome
New Tour
Escorted
2027AprMayJunSepOct
Escorted

Become immersed in the history, art and cuisine of Italy on this expertly curated tour. Beginning in its ancient capital, marvel at centuries-old Roman remains including the Colosseum, and view Michelangelo's masterpieces at the Sistine Chapel and the Accademia gallery in Florence. Traveling to the Tuscan spa town of Montecatini Terme,...

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9 days from
$2,999 pp
per person
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Belagio Lake ComoBelagio Lake ComoBelagio Lake ComoBelagio Lake ComoBelagio Lake Como
New Tour
Escorted
2027AprMayJunSep
Escorted

Explore iconic cities, delectable cuisine and remarkable scenery on this northern Italy vacation from three exceptional bases: Montecatini, Parma and Como. Travel through Tuscany to Florence and San Gimignano, where we witness centuries of art and architecture and learn about pizza and wine at a 300-year-old estate. Continuing to Emilia-Romagna,...

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9 days from
$3,799 pp
per person
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Our customers love our Italy, Southern Europe & Mediterranean tours
 Glorious Sorrento, the Amalfi Coast & Eternal Rome
29/Oct
vivien
5 stars
“Good balance between organised tours and free time. Lovely hotels. Helpful tour manager.
Collected by Trustpilot
Top to Toe of Italy
28/Oct
Susan Gibson
5 stars
“It was a great trip. A lot could be improved by providing tickets to get into the major attractions. Such as the Vatican, the coliseum. Everyone seemed to spend a lot of their time trying to get tickets to places. It was stressful and it costs more to do it...
Collected by Trustpilot
Scenic Europe by First-Class Rail: London to Rome
5/Nov
Larry Hall
4 stars
“This trip was perfect for rail enthusiasts but is not for the faint of heart! Our tour manager Cat gave a master class on how they should shepherd folks under their care. She got to know each of us well, effectively communicated to us both in person, in email, and...
Collected by Trustpilot
Iconic Cities of Spain: Barcelona to Madrid
8/Oct
customer
4 stars
“Good tour manager and hotels, and I enjoyed the included trips and meals. The walking was more challenging than anticipated so could have been highlighted more than it was.
Collected by Trustpilot
Iconic First-Class Italy: Venice, Florence & Rome
7/Oct
Mandi C
4 stars
“Offering options for free time, like cooking classes, wine tastings, would have made it over the top. Loved our tour guide!!!!
Collected by Trustpilot
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