1-877-929-7245
Tour Search



Italy, Southern Europe & Mediterranean Rail Tours & Vacations

The golden sun warms the landscape and travelers' souls in Southern Europe countries. Blue skies adjoin even bluer waters, and rolling countrysides fade into fascinating cities, where the offerings are as exotic as the surroundings. A Mediterranean trip itinerary may begin in Italy - a country renowned for its rich culture, incredible cuisine, luscious wine, pretty towns, and cosmopolitan cities. Trips may also dedicate their entirety to discovering the intricacies of this world-class destination from top to toe, exploring its ancient sites, like Pompeii, and its stunning coastlines between memorable excursions. Explore regions like Tuscany where a little bit of everything can be found, from local cuisines and wines to historic art to hiking the Tuscan hills. Mediterranean vacation packages may also venture to Spain, connecting coastal Barcelona with Madrid or Seville on the interior by high-speed train. Spanish traditions and undeniable ambiance surround each destination. Travelers can also connect Spain's cities with Portugal's incredible Douro wine region by embarking on a river cruising expedition aboard a luxurious ship. Closer to Portugal's oceanside, Porto - beloved for its Port Wine production - and the colorful city of Lisbon further weave the story of Southern Europe. Whether embarking on a guided tour or an independent adventure, it is hard not to fall in love with the vibrancy of the Mediterranean.

Explore Our Top Vacations in Italy, Southern Europe & Mediterranean

Florence Italy
Last Spaces for 2026
Save $400pp
4.3 stars(70 reviews)
Escorted
2026Sep
2027AprMayJunSepOct
8 days from
$2,999 pp $2,599 pp
View Details
Athens
Save $400pp
Escorted
2026Oct
2027MayJunSepOct
10 days from
$4,399 pp $3,999 pp
View Details
Rome Skyline
Save $400pp
4.2 stars(191 reviews)
Escorted
2026SepOct
2027AprMayJunAugSepOct
9 days from
$3,499 pp $3,099 pp
View Details
Cinque Terre
Save $400pp
4.6 stars(118 reviews)
Escorted
2026SepOct
2027MarAprMayJunJul...
11 days from
$3,899 pp $3,499 pp
View Details
Sagrada Familia Cathedral, Barcelona
Save $400pp
Escorted
2026SepOct
2027MaySepOct
11 days from
$5,799 pp $5,399 pp
View Details
Frecciarossa
Save $400pp
Escorted
2026Sep
2027AprMayJunSepOct
12 days from
$4,499 pp $4,099 pp
View Details
PIsa
Save $400pp
4.3 stars(57 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
15 days from
$5,899 pp $5,499 pp
View Details

38 results matching: Italy, Southern Europe & Mediterranean

Filters
Any
Reset
Any
Reset
Any
Reset
Any
Reset
Any
Reset
Any
Any
Reset
PIsaPIsaPIsaPIsaPIsa
Save $400pp
4.3 stars(57 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

From the alpine foothills to Sicily and all that lies between, uncover Italy's rich culture on an expertly crafted itinerary. See the highlights of Italy while traveling the country's length, delving into remarkable destinations, including Venice, Florence and Rome.  Bask in the beauty of the Amalfi Coast and marvel at the remains of...

View map

Save $400pp
15 days from
$5,899 pp $5,499 pp
per person
View Details
Piazza Navona, RomePiazza Navona, RomePiazza Navona, RomePiazza Navona, RomePiazza Navona, Rome
Save $400pp
4.5 stars(56 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

From Europe's exciting cityscapes to the stunning heights of the Swiss Alps and the idyllic Tuscan countryside, this 13-day exploration opens the doors to Europe's rich history, culture and traditions. Uncover iconic landmarks in London, sail along the romantic Seine in Paris and marvel at Switzerland's stunning Alps during a lake cruise and...

View map

Save $400pp
13 days from
$6,499 pp $6,099 pp
per person
View Details
Eiffel Tower ParisEiffel Tower ParisEiffel Tower ParisEiffel Tower ParisEiffel Tower Paris
Save $400pp
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

Discover landmark-lined rivers, alpine peaks and iconic cities while delving into the heart of Europe, relishing its best features from many perspectives. This vacation is a showcase of culture, with something new in each destination. Begin under the Eiffel Tower in Paris, cruising the Seine and touring its sites before venturing into the...

View map

Save $400pp
11 days from
$4,299 pp $3,899 pp
per person
View Details
Cinque TerreCinque TerreCinque TerreCinque TerreCinque Terre
Save $400pp
4.6 stars(118 reviews)
Escorted
2026SepOct
2027MarAprMayJunJul...
Escorted

Travel through centuries of history on this journey of cultural epicenters and romantic views. Staying in four bases, Venice, Montecatini Terme, Rome and Sorrento, uncover Italian wonders from coast to coast with the convenience of well-connected railways.  Begin in the "Floating City," discovering its canals before moving onto Tuscany to...

View map

Save $400pp
11 days from
$3,899 pp $3,499 pp
per person
View Details
Cinque TerreCinque TerreCinque TerreCinque TerreCinque Terre
Last Spaces for 2026
Save $400pp
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

This superb Mediterranean adventure features five dazzling cities - Barcelona, Carcassonne, Nîmes, Nice and Genoa - and the idyllic French and Italian Rivieras. From Barcelona's Gothic Quarter and its unique culture, discover the medieval citadel of Carcassonne, and savor a private lunch with wine tasting at a French Château. Explore...

View map

Save $400pp
12 days from
$3,799 pp $3,399 pp
per person
View Details
Sagrada Familia Cathedral, BarcelonaSagrada Familia Cathedral, BarcelonaSagrada Familia Cathedral, BarcelonaSagrada Familia Cathedral, BarcelonaSagrada Familia Cathedral, Barcelona
Save $400pp
Escorted
2026SepOct
2027MaySepOct
Escorted

Explore Spain and Portugal's greatest sites and cities, escorted by a professional Tour Manager and local guides, experiencing rich culture, striking landscapes and famous gastronomy. Starting in Barcelona, discover the city's highlights on a guided tour before traveling by high-speed First Class rail to explore Valencia and Madrid. Marvel at...

View map

Save $400pp
11 days from
$5,799 pp $5,399 pp
per person
View Details
Rome SkylineRome SkylineRome SkylineRome SkylineRome Skyline
Save $400pp
4.2 stars(191 reviews)
Escorted
2026SepOct
2027AprMayJunAugSepOct
Escorted

 Uncover the beauty of one of Europe's most enchanting regions, the captivating Amalfi Coast.     The journey begins with two nights in the "Eternal City" of Rome, where ancient landmarks and vibrant culture set the stage. From here, continue to the charming clifftop town of Sorrento, overlooking the Bay of Naples, the gateway to Capri and the...

View map

Save $400pp
9 days from
$3,499 pp $3,099 pp
per person
View Details
FrecciarossaFrecciarossaFrecciarossaFrecciarossaFrecciarossa
Save $400pp
Escorted
2026Sep
2027AprMayJunSepOct
Escorted

Experience the diverse culture of southern Italy and the sun-drenched island of Sicily on this captivating vacation, immersing yourself in history, landscapes and local cuisine. Each stop reveals layers of local character - from the unique trulli of Alberobello and the cave dwellings of Matera to Sicily's awe-inspiring Greek temples, ornate...

View map

Save $400pp
12 days from
$4,499 pp $4,099 pp
per person
View Details
Florence ItalyFlorence ItalyFlorence ItalyFlorence ItalyFlorence Italy
Last Spaces for 2026
Save $400pp
4.3 stars(70 reviews)
Escorted
2026Sep
2027AprMayJunSepOct
Escorted

 Delve into Italy's great historic cities, encountering a wealth of artistic and cultural treasures, including World Heritage sites, with guided tours of ancient Rome and the world's Renaissance capital, Florence.    With day trips to the walled Tuscan city of Lucca, Pisa's iconic tower and its gleaming white Duomo, we take a day trip to...

View map

Save $400pp
8 days from
$2,999 pp $2,599 pp
per person
View Details
Lake LucerneLake LucerneLake LucerneLake LucerneLake Lucerne
Save $400pp
Escorted
2026Oct
2027AprMayJunJulAugSep
Escorted

Experience the breathtaking wonders of two countries on one trip during this spectacular exploration of Switzerland and northern Italy. Discover sparkling Lake Lucerne from a lakefront hotel, including a trip to the summit of Mount Rigi on Europe's first mountain railway. Traveling through alpine scenery on the iconic Gotthard Panorama Express,...

View map

Save $400pp
10 days from
$4,999 pp $4,599 pp
per person
View Details
Granada AlhambraGranada AlhambraGranada AlhambraGranada AlhambraGranada Alhambra
4.5 stars(80 reviews)
Escorted
2026Sep
2027MaySepOct
Escorted

Discover the rich cultural heritage and artistry of Spain on a journey through its iconic cities. From Barcelona, travel to coastal Valencia and into the capital, Madrid, before exploring Moorish Andalucía. View the astonishing exterior of Gaudí's unfinished masterpiece in Barcelona, savor authentic cuisine in Valencia and Madrid and ...

View map

11 days from
$5,399 pp
per person
View Details
Douro Valley PortugalDouro Valley PortugalDouro Valley PortugalDouro Valley PortugalDouro Valley Portugal
Save $400pp
4.3 stars(105 reviews)
Escorted
2026AugSepOct
2027AprMayJunAugSepOct
Escorted

Flowing from northern Spain to the Atlantic Ocean, the Douro River carves our route through a rolling landscape of vineyards and idyllic locations. On this Iberian vacation, explore the Douro Valley by rail, traveling from Spain's 'Golden City' of Salamanca and through Portugal's beautiful countryside.       Experience the region's iconic wine...

View map

Save $400pp
15 days from
$5,899 pp $5,499 pp
per person
View Details
Our customers love our Italy, Southern Europe & Mediterranean tours
 Glorious Sorrento, the Amalfi Coast & Eternal Rome
8/Jul
Janet
5 stars
“Excellent trip with an excellent tour manager.
Collected by Trustpilot
Portugal, Spain & the Douro
28/Jun
customer
5 stars
“Excellent tour, great hotels Staying in the Douro was amazing
Collected by Trustpilot
First-Class Italy: Featuring Tuscany & Venice
20/Jun
David Boyer
5 stars
“This was the most amazing well planned out trip! No worries about our luggage as it was moved from each hotel for us, our tour guide Tim Hall was spot on. He was available 24/7 to assist and to answer any questions. Can’t wait for our next...
Collected by Trustpilot
Iconic Cities of Spain: Barcelona to Madrid
18/Jun
Mrs Kate HAYNES
5 stars
“Faultless organisation and excellently delivered. The Tour Manager worked tirelessly to ensure all on the tour and their interests were catered for. Much pleased with the holiday.
Collected by Trustpilot
Scenic Europe By Rail: London to Rome
10/Jun
Dion Halvorson
5 stars
“Kathy was amazing and the sights were beautiful
Collected by Trustpilot
Iconic Italy: Venice, Florence & Rome
28/May
Daniel Gavell
5 stars
“Mary was an excellent guide and we had a good group of travelers. The dinner at the steak house in Florence was one of my favorite dinners EVER and the dinner in Venice was fantastic as well. Well placed tour with plenty of free time to do our own exploring.Highly...
Collected by Trustpilot
Top to Toe of Italy
6/Jul
Shirley Brown
4 stars
“The dinner in Rome was underwhelming! Small appetizer, small pasta bland dish and small dessert - tiramisu or pancetta. Service was very slow and cursory. All tour guides were excellent. Our tour leader, Georgina was excellent.
Collected by Trustpilot
Latest Expert Advice & Inspiration