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Italy, Southern Europe & Mediterranean

Italy, Southern Europe & Mediterranean Rail Tours & Vacations

The golden sun warms the landscape and travelers' souls in Southern Europe countries. Blue skies adjoin even bluer waters, and rolling countrysides fade into fascinating cities, where the offerings are as exotic as the surroundings. A Mediterranean trip itinerary may begin in Italy - a country renowned for its rich culture, incredible cuisine, luscious wine, pretty towns, and cosmopolitan cities. Trips may also dedicate their entirety to discovering the intricacies of this world-class destination from top to toe, exploring its ancient sites, like Pompeii, and its stunning coastlines between memorable excursions. Explore regions like Tuscany where a little bit of everything can be found, from local cuisines and wines to historic art to hiking the Tuscan hills. Mediterranean vacation packages may also venture to Spain, connecting coastal Barcelona with Madrid or Seville on the interior by high-speed train. Spanish traditions and undeniable ambiance surround each destination. Travelers can also connect Spain's cities with Portugal's incredible Douro wine region by embarking on a river cruising expedition aboard a luxurious ship. Closer to Portugal's oceanside, Porto - beloved for its Port Wine production - and the colorful city of Lisbon further weave the story of Southern Europe. Whether embarking on a guided tour or an independent adventure, it is hard not to fall in love with the vibrancy of the Mediterranean.

Explore Our Top Vacations in Italy, Southern Europe & Mediterranean

Cinque Terre
Last Spaces
Escorted
2026SepOct
2027AprMayJunSepOct
12 days from
$3,799 pp $3,499 pp
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Florence Italy
Last Spaces
4.3 stars(70 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
8 days from
$3,099 pp $2,799 pp
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Athens
Escorted
2026Oct
2027MayJunSepOct
10 days from
$4,399 pp
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Rome Skyline
4.2 stars(190 reviews)
Escorted
2026AugSepOct
2027AprMayJunAugSepOct
9 days from
$3,799 pp
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Venice
Last 50 Spaces
4.6 stars(118 reviews)
Escorted
2026SepOct
2027MarAprMayJunJul...
11 days from
$3,599 pp $3,299 pp
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Sagrada Familia Cathedral, Barcelona
Escorted
2026SepOct
2027MaySepOct
11 days from
$5,899 pp
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Positano
Escorted
2026SepOct
2027AprMayJunSepOct
12 days from
$4,899 pp
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PIsa
4.3 stars(55 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
15 days from
$5,899 pp
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38 results matching: Italy, Southern Europe & Mediterranean

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VeniceVeniceVeniceVeniceVenice
Last 50 Spaces
4.6 stars(118 reviews)
Escorted
2026SepOct
2027MarAprMayJunJul...
Escorted

Travel through centuries of history on this journey of cultural epicenters and romantic views. Staying in four diverse bases, Venice, Montecatini Terme, Rome and Sorrento, uncover Italian wonders from coast to coast. Begin in the "Floating City," discovering its canals and bridges before moving into Tuscany, where we explore the Cinque...

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11 days from
$3,599 pp $3,299 pp
per person
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Piazza Navona, RomePiazza Navona, RomePiazza Navona, RomePiazza Navona, RomePiazza Navona, Rome
4.5 stars(56 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

From Europe's exciting cityscapes to the stunning heights of the Swiss Alps and the idyllic Tuscan countryside, this 13-day exploration opens the doors to Europe's rich history, culture and traditions. Uncover iconic landmarks in London, sail along the romantic Seine in Paris and marvel at Switzerland's stunning Alps during a lake cruise...

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13 days from
$6,899 pp
per person
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Eiffel Tower ParisEiffel Tower ParisEiffel Tower ParisEiffel Tower ParisEiffel Tower Paris
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

Discover landmark-lined rivers, alpine peaks and iconic cities while delving into the heart of Europe, relishing its best features from many perspectives. This vacation is a showcase of culture, with something new in each destination. Begin under the Eiffel Tower in Paris, cruising the Seine and touring its sites before venturing into the...

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11 days from
$4,299 pp $3,999 pp
per person
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PositanoPositanoPositanoPositanoPositano
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

Experience the diverse culture of southern Italy and the sun-drenched island of Sicily on this captivating vacation, immersing yourself in history, landscapes and local cuisine. Each stop reveals layers of local character - from the unique trulli of Alberobello and the cave dwellings of Matera to Sicily's awe-inspiring Greek temples, ornate...

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12 days from
$4,899 pp
per person
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Florence ItalyFlorence ItalyFlorence ItalyFlorence ItalyFlorence Italy
Last Spaces
4.3 stars(70 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

 Delve into Italy's great historic cities, encountering a wealth of artistic and cultural treasures, including World Heritage sites, with guided tours of ancient Rome and the world's Renaissance capital, Florence.    With day trips to the walled Tuscan city of Lucca, Pisa's iconic tower and its gleaming white Duomo, we take a day trip to...

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8 days from
$3,099 pp $2,799 pp
per person
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Cinque TerreCinque TerreCinque TerreCinque TerreCinque Terre
Last Spaces
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

This superb Mediterranean adventure features five dazzling cities - Barcelona, Carcassonne, Nîmes, Nice and Genoa - and the idyllic French and Italian Rivieras. From Barcelona's Gothic Quarter and its unique culture, discover the medieval citadel of Carcassonne, and savor a private lunch with wine tasting at a French Château. Explore...

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12 days from
$3,799 pp $3,499 pp
per person
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Rome SkylineRome SkylineRome SkylineRome SkylineRome Skyline
4.2 stars(190 reviews)
Escorted
2026AugSepOct
2027AprMayJunAugSepOct
Escorted

 Uncover the beauty of one of Europe's most enchanting regions, the captivating Amalfi Coast.     The journey begins with two nights in the "Eternal City" of Rome, where ancient landmarks and vibrant culture set the stage. From here, continue to the charming clifftop town of Sorrento, overlooking the Bay of Naples, the gateway to Capri and...

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9 days from
$3,799 pp
per person
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Lake LucerneLake LucerneLake LucerneLake LucerneLake Lucerne
Escorted
2027AprMayJunJulAugSep
Escorted

Experience the breathtaking wonders of two countries on one trip during this spectacular exploration of Switzerland and northern Italy. Discover sparkling Lake Lucerne from a lakefront hotel, including a trip to the summit of Mount Rigi on Europe's first mountain railway. Traveling through alpine scenery on the iconic Gotthard Panorama Express,...

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10 days from
$4,999 pp
per person
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Jeronimos MonastreyJeronimos MonastreyJeronimos MonastreyJeronimos MonastreyJeronimos Monastrey
Independent
2026AugSepOct
Independent

Where the sun meets the sea and centuries of history are presented through architecture, dancing and some of the finest wine and cuisine in the world, Portugal is a vacation destination that calls to travelers of all interests. Find what appeals to you while spending seven days exploring this idyllic piece of Europe. This thoughtfully planned...

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7 days from
$2,795 pp
per person
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Independent
2026AugSepOct
Independent

Through museum visits, guided tours and culinary experiences, delve into the history and incredible culture of Italy. This nine-day expedition follows a northerly course that takes travelers from Rome in the south to Venice on the cusp of the Adriatic Sea. Each stop along the way paints a memorable picture of Italy's immense beauty.

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9 days from
$3,495 pp
per person
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PIsaPIsaPIsaPIsaPIsa
4.3 stars(55 reviews)
Escorted
2026SepOct
2027AprMayJunSepOct
Escorted

From the alpine foothills to Sicily and all that lies between, uncover Italy's rich culture on an expertly crafted itinerary. See the highlights of Italy while traveling the country's length, delving into remarkable destinations, including Venice, Florence and Rome.  Bask in the beauty of the Amalfi Coast and marvel at the remains of...

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15 days from
$5,899 pp
per person
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TuscanyTuscanyTuscanyTuscanyTuscany
4.4 stars(315 reviews)
Escorted
2026AugSepOct
Escorted

Savor the glorious colors, aromas and flavors of Tuscany on a vacation highlighting the true beauty of this beloved Italian region. Discover the great Renaissance city of Florence, visit a historic family estate for a tour and dinner, and marvel at the iconic monuments of Pisa, including the Leaning Tower. Explore the stunning sights of...

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8 days from
$1,699 pp
per person
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Our customers love our Italy, Southern Europe & Mediterranean tours
Tuscany: Florence San Gimignano & Pisa
8/Jul
Carol
5 stars
“Ist experience with GRJ, it was great. I will be looking for my next adventure with you.
Collected by Trustpilot
 Glorious Sorrento, the Amalfi Coast & Eternal Rome
8/Jul
Janet
5 stars
“Excellent trip with an excellent tour manager.
Collected by Trustpilot
Top to Toe of Italy
4/Jul
Peter Woodland
5 stars
“A very interesting a lively holiday. GRJ anticipated, and sorted out very well, several several things that could have caused major problems.
Collected by Trustpilot
First-Class Italy: Featuring Tuscany & Venice
20/Jun
David Boyer
5 stars
“This was the most amazing well planned out trip! No worries about our luggage as it was moved from each hotel for us, our tour guide Tim Hall was spot on. He was available 24/7 to assist and to answer any questions. Can’t wait for our next...
Collected by Trustpilot
Scenic Europe By Rail: London to Rome
10/Jun
Dion Halvorson
5 stars
“Kathy was amazing and the sights were beautiful
Collected by Trustpilot
Iconic Italy: Venice, Florence & Rome
28/May
Daniel Gavell
5 stars
“Mary was an excellent guide and we had a good group of travelers. The dinner at the steak house in Florence was one of my favorite dinners EVER and the dinner in Venice was fantastic as well. Well placed tour with plenty of free time to do our own exploring.Highly...
Collected by Trustpilot
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